Glucose Deprivation in Rat Striatal Spiny Neurons Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen
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چکیده
and Glucose Deprivation in Rat Striatal Spiny Neurons Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.30.1.171 1999;30:171-179 Stroke. http://stroke.ahajournals.org/content/30/1/171 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Sodium influx plays a major role in the membrane depolarization induced by oxygen and glucose deprivation in rat striatal spiny neurons.
BACKGROUND AND PURPOSE Striatal spiny neurons are selectively vulnerable to ischemia, but the ionic mechanisms underlying this selective vulnerability are unclear. Although a possible involvement of sodium and calcium ions has been postulated in the ischemia-induced damage of rat striatal neurons, the ischemia-induced ionic changes have never been analyzed in this neuronal subtype. METHODS We...
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BACKGROUND AND PURPOSE Neuronal Na(+)/Ca(2+) exchanger plays a relevant role in maintaining intracellular Ca(2+) and Na(+) levels under physiological and pathological conditions. However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes. METHODS We investigated the effects of bepri...
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We have studied the electrophysiological effects of glucose deprivation on morphologically identified striatal neurons recorded from a corticostriatal slice preparation. The large majority of the recorded cells were spiny neurons and responded to aglycemia with a slow membrane depolarization coupled with a reduction of the input resistance. In voltage-clamp experiments aglycemia caused an inwar...
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AbstractIn the present work we set out to investigate the neuroprotective effects of noscapine (0.5-2 µM) in presence of D-glucose on primary murine foetal cortical neurons after oxygen–glucose deprivation/24 hrs recovery. Cell viability, nitric oxide production and intracellular calcium ([ca2+]i) levels were evaluated by MTT assay, the modified Griess method and Fura-2 respectively. 25 and 100...
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